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Season 22 Episode
- Season 22 Luke Wilson, Julie Chen, Lee Brice
- Season 22 Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers
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- Season 22 Tina Fey, Moody McCarthy, Kevin Drew
- Season 22 Bill Maher, Henrik Lundqvist, Spoon
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- Season 22 Anderson Cooper, Gina Rodriguez, Hatsune Miku
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- Season 22 Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley
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- Season 22 Jennifer Lopez, Rob Riggle, Kimbra
- Season 22 Whoopi Goldberg, Jimmy Page, Mapei
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- Season 22 Katie Holmes, Alex Zanardi
- Season 22 Steve Carell, Martha Stewart, OK Go
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- Season 22 Kristin Chenoweth; Chris Young
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- Season 22 Emma Stone Top, Marcus Mariota, Bob Seger
- Season 22 New Holiday Toys, Anna Kendrick, Charli XCX
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- Season 22 Donald Trump, Chelsea Peretti, Foxygen
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- Season 22 Larry David, Dan Patrick, Sleater-Kinney
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- Season 22 Louis CK, Nicolle Wallace, the Lone Bellow
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- Season 22 Viola Davis, Ben Schwartz, Marty Stuart
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- Season 22 Aziz Ansari, Brian Kiley, Ben Howard
- Season 22 Jack Hanna, Sharon Jones and the Dap-Kings
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- Season 22 Martin Short, Bettye Lavette
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- Season 22 Steve Carell, Dr. Cornel West
- Season 22 Courtney Love, Chris Elliott, Rhiannon Giddens
- Season 22 Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear
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- Season 22 Dakota Johnson, David Tochinskiy, Twin Shadow
- Season 22 Will Smith, Grizfolk
- Season 22 Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko
- Season 22 Kid Scientists, Sean Hayes, Judah & the Lion
- Season 22 Helen Mirren, the 2015 Daytona 500 winner, Steve Earle
- Season 22 Matthew Broderick, Ellie Kemper, JD McPherson
- Season 22 Julianna Margulies, Eric Ripert, Glass Animals
- Season 22 Kevin Spacey, Lily James, Alabama Shakes
- Season 22 Patricia Arquette, Will Butler
- Season 22 Kelsey Grammer, Stevie Wonder
- Season 22 Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew
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- Season 22 Will Ferrell, Glen Hansard
- Season 22 Norm MacDonald, Theo James
- Season 22 Ben Stiller, Tove Lo
- Season 22 Bill O'Reilly, Aubrey Plaza
- Season 22 James Franco, Jake Johannsen, Action Bronson
- Season 22 Neil Patrick Harris, Charlie Cox, the Suffers
- Season 22 David Duchovny, Josh Gad, Houndmouth
- Season 22 Sen. Al Franken, Billy Eichner, David Sanborn
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- Season 22 Sarah Jessica Parker, Julie Chen, Asleep at the Wheel
- Season 22 Billy Crystal, Chris Russo, Chris Stapleton
- Season 22 Michael J. Fox, Iron & Wine, Ben Bridwell
- Season 22 Kevin James, Tom Dreesen, Tracy Chapman
- Season 22 Alec Baldwin, John Mayer
- Season 22 John Travolta, Amy Schumer, the Waterboys
- Season 22 Piedmont Bird Callers, Paul Rudd
- Season 22 Bruce Willis, Dawes
- Season 22 Robert Downey Jr., Chris Russo, Elvis Costello
- Season 22 Jerry Seinfeld, Jason Isbell & Amanda Shires
- Season 22 Scarlett Johansson, John Mellencamp, Todd Rundgren
- Season 22 Michael Keaton, Future Islands
- Season 22 Jack Hanna, John Popper
- Season 22 First Lady Michelle Obama Hootie and the Blowfish
- Season 22 Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor
- Season 22 President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile
- Season 22 Reese Witherspoon, Nathan Lane, Mumford & Sons
- Season 22 Martin Short, Norah Jones
- Season 22 Tina Fey, First Aid Kit
- Season 22 Ray Romano, Brian Regan, Dave Matthews Band
- Season 22 Howard Stern, Don Rickles
- Season 22 Bill Clinton, Adam Sandler
- Season 22 Julia Roberts, Paul Shaffer, Ryan Adams
- Season 22 Al Pacino, George Clooney, Tom Waits
- Season 22 Oprah Winfrey, Norm Macdonald
- Season 22 Tom Hanks, Eddie Vedder
- Season 22 Bill Murray, Bob Dylan
- Season 22 The Final Late Show with David Letterman
- Season 22 Episode 149
Late Show with David Letterman - Season 22 Episode 104 Bill O'Reilly, Aubrey Plaza
6.37 63 minutes 
